Sperling Prostate Center

Lycopene and Prostate Cancer

UPDATE: 4/24/2023
Originally published 3/20/2014

It’s almost 10 years since we posted the blog below, but it’s a good time to update the information in it. In fact, a 10-year published review of plant-derived phytochemicals—particularly lycopene–and their effect on the prostate presents a comprehensive summary of experimental findings.[i]

For example, at the molecular level, laboratory experiments using prostate cancer (PCa) cell cultures as well as studies of lab animals implanted with PCa tumor cells suggest that lycopene:

  • Has an anti-proliferative effect as well as encouraging programmed cancer cell death (apoptosis).
  • Appears to inhibit the ability of cancer cells to synthesize cholesterol, thus depriving them of an energy resource.
  • Interfered directly with androgen signaling.
  • Blocked the tumor’s ability to develop its own blood supply (angiogenesis).

These and other effects are due to the molecular mechanisms of lycopene on cellular receptors and signaling pathways, all of which are increasingly better understood through advances in research methods that allow analysis at the level of genes. There is no doubt that lycopene can influence cellular receptors and signaling pathways.

The authors believe that lycopene and other carotenoids such as beta carotene hold promise for creating new approaches to preventing and treating prostate cancer.

They write, “The diversity of carotenoids and their influence on the human organism and prostate in particular still remains a source of fascinating, surprising findings. Undoubtedly, numerous discoveries in this field are awaiting us in the following years.”


“Let food be thy medicine and medicine be thy food.” So said Hippocrates, the ancient Greek physician whose famous oath for new doctors established important medical ethics. Wouldn’t it be great if diseases like prostate cancer could be cured—or altogether prevented—by eating the right foods?

The plant pigment lycopene, found in foods such as tomatoes, watermelon, and apricots, helps protect fruits and vegetables from stress, and enables absorption of the sun’s energy. It has been shown in human and animal studies to affect cellular antioxidant activity and communication. It has been the subject of numerous studies on the connection between dietary lycopene and a reduced risk of prostate cancer. Laboratory studies have helped to shed light on how lycopene impacts prostate cancer cells.

For example, prostate cancer cells treated with lycopene had less effective cell division, which retarded their growth. It also lowered the cells’ cholesterol level, a fuel that cancer needs in order to proliferate, thus inhibiting cell growth and leading to damage. There is also a theory that lycopene changes the ability of prostate cancer to take up androgens, which appear to feed certain prostate cancer cell lines.

Animal studies have demonstrated a potential preventive role for lycopene. Mice or rats fed various forms of lycopene (food products or supplements) showed a reduced incidence of prostate cancer than those on normal diets. Another possible benefit was seen in animals that survived longer with prostate cancer, and had smaller tumors, when fed lycopene than those without it.

Clinical trials with humans reveal mixed results, perhaps as a result of varying study designs. Generally, it has been observed that the higher the level of lycopene in the blood, the less chance of developing prostate cancer. This observation occurred in more than one study, lending reliability. Another study found that men at risk of prostate cancer (from hereditary factors) who consumed lycopene were at reduced risk of developing the disease than men who did not.

There are two ways to increase lycopene intake: consume more foods rich in it, or take supplements. The food most often studied is cooked tomatoes (in red sauce or red tomato paste); cooking the tomatoes makes the lycopene more concentrated and available, and when consumed with healthy fat such as olive oil, it is more readily absorbed into the body. As for supplements, as little as 10mg per day can be beneficial, and no harsh side effects have been seen.

What’s truly important for me, as a physician who specializes in targeted ablation of prostate cancer tumors, is the implication that my patients can use healthy eating habits before and after treatment to take advantage of lycopene’s potential benefits to lessen the chance of recurrence. Remember that targeted ablation preserves living, functional prostate tissue in the areas not treated. Foods such as cooked tomatoes can be easily added to delicious dishes; and watermelon makes a great dessert or snack alternative to rich, processed “treats” with little nutritional value. Why wait until science “proves” that lycopene is a worthy opponent of prostate cancer? Boost your lycopene levels and live better, live longer. To your health!

NOTE: This content is solely for purposes of information and does not substitute for diagnostic or medical advice. Talk to your doctor if you are experiencing pelvic pain, or have any other health concerns or questions of a personal medical nature.

[i] Duli?ska-Litewka J, Sharoni Y, Halubiec P, Lazarczyk A et al. Recent Progress in Discovering the Role of Carotenoids and Their Metabolites in Prostatic Physiology and Pathology with a Focus on Prostate Cancer—A Review—Part I: Molecular Mechanisms of Carotenoid Action. Antioxidants (Basel). 2021 Apr; 10(4): 585.


About Dr. Dan Sperling

Dan Sperling, MD, DABR, is a board certified radiologist who is globally recognized as a leader in multiparametric MRI for the detection and diagnosis of a range of disease conditions. As Medical Director of the Sperling Prostate Center, Sperling Medical Group and Sperling Neurosurgery Associates, he and his team are on the leading edge of significant change in medical practice. He is the co-author of the new patient book Redefining Prostate Cancer, and is a contributing author on over 25 published studies. For more information, contact the Sperling Prostate Center.

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